Paper on highly efficient chromatographic separation of PEGs
In a new open-access publication, we present results of our long-lasting investigations on the chromatographic separation of polyethylene glycols (PEGs). Syntheses of polymers like PEGs always yield products with a distribution of molar weights. The broader such distribution, the less defined are the product’s physico-chemical properties.
The paper demonstrates how pure single homologs of PEG can be isolated from such distributed mixtures by reversed-phase chromatography. Such so-called monodisperse PEGs can serve as highly valuable standards for analytical techniques, or for producing pharmaceuticals with very well defined properties.
The work presents a thermodynamic analysis of detailed, analytical-scale experimental data. Based on this, highly accurate modelling approaches are established that will support the development of corresponding separation processes at larger scale.
Malvina Supper, Kathleen Heller, Jakob Söllner, Tuomo Sainio, Malte Kaspereit:
Separation of Molar Weight-Distributed Polyethylene Glycols by Reversed-Phase Chromatography — Analysis and Modeling Based on Isocratic Analytical-Scale Investigations.
Processes 10(11) (2022) 11
The work was supported by the Collaborative Research Centre CRC 1411 “Design of Particulate Products”.